Idylla EGFR Mutation Assay

51 EGFR mutations in exons 18, 19, 20 and 21

~150 minutes assay turnaround time

< 2 minutes hands-on time

Only 1 slice of FFPE tissue required

Highly sensitive & standardized

Suitable for any lab

Idylla EGFR Mutation Assay (RUO)

A0061/6

The fully automated Idylla^TM EGFR Mutation Assay covers 51 mutations in exons 18–21 in a single cartridge using only 1 FFPE tissue section from metastatic NSCLC showing a high concordance of >95% compared with reference methods^1,2

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Specimen requirements

One of the biggest challenges in oncology biomarker testing is the ability to obtain samples of sufficient size and quality. With the Idylla^TM System only a minimal amount of sample is needed

1x 5 μm FFPE tissue section
Neoplastic cells ≥10% - if less, macrodissection is required

Idylla assay and next generation sequencing: an integrated EGFR mutational testing algorithm

De Luca et al. Journal of Clinical Pathology 2018;71:745-750.

The Idylla^TM EGFR Mutation Test was compared to retrospective NGS results obtained with the Ion Torrent NGS system showing 100% concordance for the samples that had a valid NGS result. In addition the Idylla^TM EGFR Mutation Test was able to rescue 80% of the EGFR samples whose assessment was unsuccessful with NGS, identifying several actionable EGFR mutations.

Idylla Research Assays

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